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OCR: Forbed, As ADH is secreted, water is normally ab smolality, with the subsequent elevation of urine c only a Following desmopressin administration erved, In small additional rise in osmolality is obs entrate to diabetes insipidus, the urine fails to conc f ADH, twice the plasma osmolality due to lack hence plasma osmolality rises. The urine istration ofconcentrates adequately only after admir as no effectdesmopressin. Desmopressin therefore } sipidus on patients with nephrogenic diabetes ir e to ADH. where the renal tubules are unresponsi treated Diabetes insipidus may be masked in un ed only hypopituitarism, sometimes being reves with after hormone replacement, particularly ortisol